Umhlaba omnye umlo omnye
─Intsebenziswano yamazwe ngamazwe ukwakha uluntu lwehlabathi jikelele lwendawo efanayo ekuphenduleni umngeni we-COVID-19
Intsholongwane ye-Corona egqugqisayo kwihlabathi liphela ikhokelele kubhubhani we-COVID-19 oqhubekayo kwihlabathi.Inoveli coronavirus ayinamida, akukho lizwe liya kusindiswa kweli dabi lokulwa ne-COVID-19.Ukusabela kulo bhubhani we-COVID-19 wehlabathi jikelele, iLiming Bio-Products Corp yenza igalelo ukuxhasa impilo-ntle yoluntu lwethu lwehlabathi.
Umhlaba wethu ngoku ujongene nefuthe elingazange libonwe ngaphambili lenoveli yesifo se-coronavirus ka-2019 (COVID-19) bhubhane.Ukuza kuthi ga ngoku, alikho ichiza elisebenzayo lokunyanga esi sifo.Nangona kunjalo, uvavanyo loxilongo oluninzi lwenzelwe ukuchongwa kwe-COVID-19.Olu vavanyo lusekwe kwiindlela zemolekyuli okanye ze-serological zokubona inoveli ye-coronavirus ethile ye-nucleic acid okanye i-antibody biomarkers.Njengoko i-COVID-19 ifikelele kwisimo sobhubhane, ukufunyaniswa kwangoko kosulelo lwenoveli ye-coronavirus kubalulekile ekuvavanyeni ukusasazeka kwale ntsholongwane kwaye iqulathe, kodwa uvavanyo olugqibeleleyo lokusetyenziswa kwendawo yonke alukabikho.Kufuneka sazi ukuba loluphi uvavanyo olunokuthi lusetyenziswe ekuvavanyeni, ekuxilongeni nasekubekeni iliso usulelo lwe-COVID-19, kwaye yintoni imida yalo.Kubaluleke kakhulu indlela yokusebenzisa kakuhle ezi zixhobo zenzululwazi kunye nokunceda ukuchonga nokulawula ukuvela kwesi sifo sisasazeka ngokukhawuleza kunye nesibi.
Injongo yokufunyaniswa kwenoveli yekoronavirus kukufumanisa ukuba umntu unosulelo lwe-COVID-19 okanye umntu onesifo se-asymptotic onokusasaza intsholongwane ngokuthe cwaka, ukubonelela ngolwazi olubalulekileyo lokukhokela ekwenziweni kwezigqibo zonyango.Izifundo zangaphambili zibonise ukuba i-70% yezigqibo zeklinikhi zixhomekeke kwiziphumo zovavanyo.Xa kusetyenziswa iindlela ezahlukeneyo zokufumanisa, iimfuno zeekiti ze-reagent reagent nazo zihlukile.
Umfanekiso woku-1
Umfanekiso 1:Umzobo obonisa amanqanaba aphambili amanqanaba ebhayomarker ngokubanzi ngexesha lexesha losulelo lwe-COVID-19.I-X-axis ibonisa inani leentsuku zosulelo, kwaye i-Y-axis ibonisa umthamo wentsholongwane egazini, ukuxinwa kwee-antigens, kunye nokuxinwa kwee-antibodies kumaxesha ahlukeneyo.I-antibody ibhekisa kwi-IgM kunye ne-IgG antibodies.Zombini i-RT-PCR kunye nokufunyanwa kwe-antigen zisetyenziselwa ukubona ubukho okanye ukungabikho kwenoveli coronavirus, obubungqina obuthe ngqo bokubhaqwa kwesigulana kwangoko.Kwiveki yosulelo lwentsholongwane, ukufunyanwa kwe-PCR, okanye ukufunyanwa kwe-antigen kuyakhethwa.Emva kosulelo lwenoveli ye-coronavirus malunga neentsuku ezi-7, i-antibody ye-IgM ngokuchasene ne-coronavirus yenoveli iye yanda kancinci egazini lomguli, kodwa ixesha lobukho lifutshane, kwaye ukugxila kwayo kuncipha ngokukhawuleza.Ngokwahlukileyo koko, i-antibody ye-IgG echasene nentsholongwane ibonakala kamva, ihlala malunga neentsuku ezili-14 emva kosulelo lwentsholongwane.I-concentration ye-IgG ikhula ngokuthe ngcembe, kwaye ihlala ixesha elide egazini.Ke, ukuba i-IgM ifunyenwe egazini lesigulana, oko kuthetha ukuba intsholongwane isandula ukosulela, nto leyo iluphawu lokuqala losulelo.Xa i-antibody ye-IgG ifunyenwe egazini lesigulana, oko kuthetha ukuba usulelo lwentsholongwane sele lunexesha elithile.Ikwabizwa ngokuba yintsholongwane kade okanye usulelo lwangaphambili.Ngokuqhelekileyo kubonakala kwizigulane ezikwisigaba sokubuyisela.
Iimpawu zebhayoloji yenoveli coronavirus
Inoveli coronavirus yintsholongwane yeRNA, eyenziwe ngeeproteni kunye ne-nucleic acid.Intsholongwane ihlasela inginginya (umntu) emzimbeni, ingena kwiiseli ngokubopha indawo ye-receptor ehambelana ne-ACE2, kwaye iphindaphindeke kwiiseli ezibambayo, ibangela ukuba amajoni omzimba aphendule kubahlaseli bamanye amazwe kwaye avelise amajoni athile omzimba.Ke ngoko, i-vial nucleic acids kunye ne-antigens, kunye ne-antigens ezithile ezichasene ne-coronavirus entsha zinokuthi zisetyenziswe njengee-biomarker ezithile zokubona inoveli coronavirus.Ukufunyanwa kwe-nucleic acid, itekhnoloji ye-RT-PCR yeyona isetyenziswa kakhulu, ngelixa iindlela ze-serological ziqhele ukusetyenziswa ukubhaqa inoveli ye-coronavirus-specific antibodies.Okwangoku, kukho iindlela ezahlukeneyo zovavanyo ezikhoyo esinokuzikhethela ukuvavanya usulelo lwe-COVID-19 [1].
Imigaqo esisiseko yeendlela eziphambili zovavanyo lwenoveli coronavirus
Uvavanyo oluninzi lwe-COVID_19 luyafumaneka ukuza kuthi ga ngoku, kunye nezixhobo zovavanyo ezininzi ezifumana imvume phantsi kogunyaziso losetyenziso olungxamisekileyo yonke imihla.Nangona uphuhliso olutsha lovavanyo luphuma namagama amaninzi ahlukeneyo kunye neefomathi, zonke iimvavanyo zangoku ze-COVID_19 ngokusisiseko zixhomekeke kubuchwephesha obumbini obuphambili: ukufunyanwa kwe-nucleic acid yentsholongwane ye-RNA kunye ne-serological immunoassays efumanisa izilwa-ntsholongwane ezikhethekileyo (IgM kunye ne-IgG).
01. Ukufumanisa i-Nucleic acid
Reverse transcription-polymerase chain reaction (RT-PCR), loop-mediated isothermal amplification (LAMP), kunye nolandelelwano lwesizukulwana esilandelayo (NGS) zezona ndlela ziqhelekileyo ze-nucleic acid zokubona inoveli coronavirus RNA.I-RT-PCR luhlobo lokuqala lovavanyo lwe-COVID-19, olucetyiswa yiWorld Health Organisation (WHO) kunye neZiko lase-US loLawulo lweSifo noThintelo (CDC).
02.Ukufunyanwa kwe-antibody ye-serological
I-antibody yiprotheyini ekhuselayo eveliswa emzimbeni womntu ukuphendula usulelo lwentsholongwane.I-IgM luhlobo lokuqala lwe-antibody ngelixa i-IgG iyi-antibody yodidi lwamva.Iserum okanye isampulu yeplasma ihlala ivavanyelwa ubukho beentlobo ezithile ze-IgM kunye ne-IgG ye-antibody ukuze kuhlolwe amanqanaba abukhali kunye nenqanaba lokuphola losulelo lwe-COVID-19.Ezi ndlela zokufumanisa ezisekelwe kwi-antibody ziquka i-colloidal gold immunochromatography assay, i-latex okanye i-fluorescent microsphere immunochromatography, i-enzyme-linked immunosorbent assay (ELISA), kunye ne-chemiluminescence assay.
03.Ukufunyanwa kwe-antigen yentsholongwane
I-Antigen sisakhiwo kwintsholongwane eyaziwayo ngumzimba womntu obangela ukuba inkqubo yokukhusela i-immune ivelise izilwa-buhlungu zokucoca intsholongwane egazini kunye nezicubu.I-antigen yentsholongwane ekhoyo kwintsholongwane inokujoliswa kwaye ibonwe ngokusebenzisa i-immunoassay.Njengentsholongwane ye-RNA, ii-antigens zentsholongwane zikwakho kwindlela yokuphefumla yabantu abosulelekileyo kwaye zinokusetyenziselwa ukuxilonga inqanaba losulelo lwe-COVID-19.Ke ngoko, kuhlala kucetyiswa ukuba kuqokelelwe iisampulu zokuphefumla eziphezulu ezinje ngamathe, i-nasopharyngeal kunye ne-oropharyngeal swabs, isikhohlela esikhohlela nzulu, i-bronchoalveolar lavage fluid (BALF) kuvavanyo lokuqala lwe-antigen.
Ukukhetha iindlela zokuvavanya i-coronavirus entsha
Ukukhetha indlela yokuvavanya kubandakanya izinto ezininzi, kubandakanya ukusetwa kwezonyango, ulawulo lomgangatho wovavanyo, ixesha lokutshintsha, iindleko zovavanyo, iindlela zokuqokelela iisampulu, iimfuno zobugcisa zabasebenzi baselabhoratri, izixhobo kunye neemfuno zezixhobo.Ukufunyanwa kwe-nucleic acids okanye i-antigens yentsholongwane kukubonelela ngobungqina obuthe ngqo bobukho beentsholongwane kunye nokuqinisekisa ukuxilongwa kosulelo lwe-coronavirus yenoveli.Nangona zininzi iindlela zokufunyanwa kwe-antigen, uvakalelo lwabo lokubona inoveli coronavirus lusezantsi ngokwethiyori kunolwandiso lwe-RT-PCR.Uvavanyo lwe-anti-virus kukufumanisa izilwa-ntsholongwane ezilwa nentsholongwane eziveliswa kumzimba womntu, osemva kwexesha kwaye kaninzi azinakusetyenziselwa ukubhaqwa kwangoko ngexesha losulelo lwentsholongwane.Ukusetwa kweklinikhi kwizicelo zokubona kungahluka, kwaye iindawo zokuqokelela iisampulu zinokwahluka.Ukufunyanwa kwe-viral nucleic acids kunye ne-antigens, i-specimen kufuneka iqokelelwe kwindlela yokuphefumula apho intsholongwane ikhona khona, njenge-nasopharyngeal swabs, i-oropharyngeal swabs, i-sputum, okanye i-bronchoalveolar lavage fluid (BALF).Ukufunyaniswa okusekelwe kwi-anti-virus, isampuli yegazi kufuneka iqokelelwe kwaye ihlolwe ubukho be-anti-virus ethile (IgM/IgG).Nangona kunjalo, iziphumo zovavanyo lwe-antibody kunye ne-nucleic acid zinokuncedisana.Umzekelo, xa iziphumo zovavanyo ziyi-nucleic acid-negative, i-IgM-negative kodwa i-IgG-positive, ezi ziphumo zibonisa ukuba isigulana asiyithwali intsholongwane okwangoku, kodwa sifunyenwe kusulelo lwenoveli ye-coronavirus.[2]
Izinto eziluncedo kunye nokungalunganga kuvavanyo lwe-coronavirus entsha
KwiProtokholi yokuHlola kunye noNyango lweNoveli yeCoronavirus Pneumonia (Inguqulo yesi-7) (Ikhutshwe yiKomishoni yezeMpilo yeSizwe kunye noLawulo lweSizwe lwezoNyango zesiNtu zaseTshayina ngoMatshi 3, 2020), uvavanyo lwe-nucleic acid lusetyenziswa njengendlela esemgangathweni yegolide yokufunyaniswa kwenoveli. usulelo lwe-coronavirus, ngelixa uvavanyo lwe-antibody lukwathathwa njengenye yeendlela zokuqinisekisa ukuxilongwa.
Iziphumo ze-Pathogenic kunye ne-serological
(1) Iziphumo ze-Pathogenic: I-Novel coronavirus nucleic acid inokubonwa kwi-nasopharyngeal swabs, isikhohlela, i-secretions ephantsi yokuphefumula, igazi, ilindle kunye nezinye iisampuli usebenzisa i-RT-PCRand / okanye iindlela ze-NGS.Ichaneke ngakumbi ukuba imizekelo ifunyenwe kwindlela esezantsi yokuphefumla (isikhohlela okanye ukutsalwa kwendlela yomoya).Iisampuli kufuneka zingeniswe ukuze zivavanywe ngokukhawuleza emva kokuba ziqokelelwe.
(2) Iziphumo ze-Serological: I-NCP ye-virus ethile ye-IgM iya kubonakala malunga neentsuku ze-3-5 emva kokuqala;I-IgG ifikelela kwi-titration yokunyuka kwe-4-fold-fold ngexesha le-convalescence xa kuthelekiswa nesigaba esinzima.
Nangona kunjalo, ukhetho lweendlela zovavanyo luxhomekeke kwindawo, imimiselo yezonyango, kunye noseto lweklinikhi.E-USA, i-NIH ikhuphe iziKhokelo zoNyango ze-Coronavirus (COVID-19) ngo-2019 (iNdawo iHlaziywe: ngo-Epreli 21,2020 ) kwaye i-FDA ikhuphe uMgaqo-nkqubo woVavanyo lwe-Diagnostic lweSifo se-Coronavirus-2019 ngexesha likaNgxamiseko lweMpilo kaRhulumente (ikhutshwe nge-16 kaMatshi, i-2020 ), apho uvavanyo lwe-serological lwe-antibodies ye-IgM / IgG ekhethiweyo kuphela njengovavanyo lokuhlola.
Indlela yokubona iNucleic Acid
I-RT_PCR luvavanyo olubuthathaka kakhulu lwe-nucleic acid eyilelwe ukukhangela ukuba i-RNA ye-coronavirus yenoveli ikhona na kwindlela yokuphefumla okanye enye isampuli.Iziphumo zovavanyo eziqinisekileyo ze-PCR zithetha ubukho benoveli ye-coronavirus RNA kwisampulu yokuqinisekisa usulelo lwe-COVID-19.Iziphumo zovavanyo lwe-PCR ezingalunganga azithethi ukungabikho kosulelo lwentsholongwane kuba lunokuchatshazelwa ngumgangatho ombi wesampulu okanye ixesha lesifo kwinqanaba elifunyenweyo, njl.Nangona i-RT-PCR luvavanyo olubuthathaka kakhulu, inezithintelo ezininzi.Iimvavanyo ze-RT-PCR zingaba nzima kwaye zichithe ixesha, zixhomekeke ngokubalulekileyo kumgangatho ophezulu wesampuli.Oku kunokuba ngumceli mngeni kuba isixa sentsholongwane ye-RNA ayihlukanga kakhulu kuphela phakathi kwezigulana ezohlukeneyo kodwa inokwahluka phakathi kwesigulana esinye ngokuxhomekeke kumanqaku exesha xa isampuli iqokelelwa kunye nezigaba zosulelo okanye ukuqala kweempawu zeklinikhi.Ukufumanisa inoveli coronavirus kufuna iisampulu ezikumgangatho ophezulu eziqulethe inani elaneleyo le-RNA yentsholongwane.
Uvavanyo lwe-RT-PCR lunokunika iziphumo ezingalunganga ezingachanekanga (ezingeyonyani) kwezinye izigulana ezinosulelo lwe-COVID-19.Njengoko sisazi, ezona ndawo ziphambili zosulelo lwenoveli coronavirus zikwimiphunga kunye nephecana lokuphefumla elisezantsi, elifana ne-alveoli kunye ne-bronchi.Ke ngoko, umfuziselo wesikhohlela osuka kukhohlokhohlo olunzulu okanye kwi-bronchoalveolar lavage fluid (BALF) ebonwa njengobona buntununtunu buphezulu bokubhaqwa kwentsholongwane.Nangona kunjalo, ekusebenzeni kweklinikhi, iisampulu zihlala ziqokelelwa kwindawo ephezulu yokuphefumula ngokusebenzisa i-nasopharyngeal okanye i-oropharyngeal swabs.Ukuqokelela ezi sampuli akukhathali kwizigulana kuphela kodwa kufuna abasebenzi abaqeqeshwe ngokukodwa.Ukwenza isampulu ingangeneleli okanye ibe lula, kwezinye iimeko izigulane zinokunikwa i-swab yomlomo kwaye zivumele ukuba zithathe isampuli kwi-buccal mucosa okanye ukuzixuba ngolwimi.Ngaphandle kwe-RNA yentsholongwane eyaneleyo, i-RT-qPCR inokubuyisela iziphumo zovavanyo olungeyonyani.Kwiphondo laseHubei, eChina, uvakalelo lwe-RT-PCR ekubhaqweni kokuqala kwabikwa kuphela malunga ne-30% -50%, kunye nomyinge we-40%.Izinga eliphezulu lobuxoki-negative kusenokwenzeka ukuba libangelwe kukungonelanga kwesampulu.
Ukongeza, uvavanyo lwe-RT-PCR lufuna abasebenzi abaqeqeshwe kakhulu ukuba benze amanyathelo anzima okutsalwa kwe-RNA kunye nenkqubo yokukhulisa i-PCR.Ikwafuna umgangatho ophezulu wokhuseleko lwebhayoloji, indawo eyodwa yaselabhoratri, kunye nesixhobo sePCR sexesha lokwenyani.E-China, uvavanyo lwe-RT-PCR yokufunyaniswa kwe-COVID-19 kufuneka lwenziwe kwiilebhu zenqanaba lesi-2 le-biosafety (BSL-2), ngokhuseleko lwabasebenzi kusetyenziswa i-biosafety level 3 (BSL-3) practice.Phantsi kwezi mfuno, ukusukela ekuqaleni kukaJanuwari ukuya ekuqaleni kukaFebruwari ka-2020, umthamo we-CDC yase-China yase-Wuhan yakwazi ukubona kuphela amakhulu ambalwa amatyala ngosuku.Ngokuqhelekileyo, oku akuyi kuba yingxaki xa kuvavanywa ezinye izifo ezosulelayo.Nangona kunjalo, xa ujongana nobhubhane wehlabathi onje nge-COVID-19 enokuba zizigidi zabantu ukuba bavavanywe, i-RT-PCR iba ngumba obalulekileyo ngenxa yeemfuno zayo zezixhobo ezikhethekileyo zelebhu okanye izixhobo zobugcisa.Ezi zinto zingalunganga zinokunciphisa i-RT-PCR ukuba isetyenziswe njengesixhobo esisebenzayo sokuhlola, kwaye kunokukhokelela ekulibazisekeni kweengxelo zeziphumo zovavanyo.
Indlela yokufumanisa i-antibody ye-serological
Ngenkqubela phambili yekhosi yesifo, ngakumbi kumanqanaba aphakathi kunye nasemva kwexesha, izinga lokufunyanwa kwe-antibody liphezulu kakhulu.Uphononongo kwisibhedlele i-Wuhan Central South lubonise ukuba izinga lokufunyanwa kwe-antibody linokufikelela ngaphezulu kwe-90% kwiveki yesithathu yosulelo lwe-COVID-19.Kwakhona, i-antibody yimveliso yokuphendula komzimba womntu ngokuchasene ne-coronavirus entsha.Uvavanyo lwe-antibody lubonelela ngeenzuzo ezininzi ngaphezulu kwe-RT-PCR.Okokuqala, uvavanyo lwe-serological antibody lulula kwaye lukhawuleza.Iimvavanyo ze-Antibody lateral flow zingasetyenziselwa indawo yokukhathalela ukuhambisa iziphumo kwimizuzu eyi-15.Okwesibini, into ekujoliswe kuyo echongiweyo luvavanyo lwe-serological yi-antibody, eyaziwa ngokuba izinzile ngakumbi kune-RNA yentsholongwane.Ngexesha lokuqokelela, ukuthuthwa, ukugcinwa kunye novavanyo, iisampulu zovavanyo lwe-antibody zihlala zizinzile ngakumbi kunesampulu ye-RT-PCR.Okwesithathu, ngenxa yokuba i-antibody isasazwa ngokulinganayo kujikelezo lwegazi, kukho umahluko omncinci wesampulu xa kuthelekiswa novavanyo lwe-nucleic acid.Umthamo wesampulu ofunekayo kuvavanyo lwe-antibody umncinci.Ngokomzekelo, i-microliter ye-10 yegazi ye-finger-prick yanele ukusetyenziswa kuvavanyo lwe-antibody lateral flow.
Ngokubanzi, uvavanyo lwe-antibody lukhethwa njengesixhobo esongezelelweyo sokufunyanwa kwe-nucleic acid ukuphucula izinga lokubona inoveli coronavirus ngexesha lezifundo zesifo.Xa uvavanyo lwe-antibody lusetyenziswa kunye novavanyo lwe-nucleic acid, lunokonyusa ukuchaneka kovavanyo lokufunyaniswa kwe-COVID19 ngokunciphisa iziphumo ezinokubakho zobuxoki kunye nezobuxoki-zimbi.Isikhokelo sokusebenza samanje asicebisi ukusebenzisa iintlobo ezimbini zovavanyo ngokwahlukileyo njengefomathi yokufumanisa ezimeleyo kodwa kufuneka isetyenziswe njengefomathi edibeneyo.[2]
Umfanekiso 2:Ukutolikwa okuchanekileyo kwe-nucleic acid kunye neziphumo zovavanyo lwe-antibody ekubhaqweni kosulelo lwenoveli lwe-coronavirus
Umfanekiso 3:ILiming Bio-Products Co., Ltd.-Inoveli ye-coronavirus ye-IgM/IgG ye-antibody ephindwe kabini yovavanyo olukhawulezayo lweKit (StrongStep®Uvavanyo oluKhawulezayo lwe-SARS-CoV-2 IgM/IgG Antibody, iLatex Immunochromatography)
Umfanekiso 4:ILiming Bio-Products Co., Ltd. – StrongStep®Inoveli coronavirus (SARS-CoV-2) Multiplex Real-Time PCR kit (ukubona imizila yemfuza ezintathu, fluorescent probe indlela).
Phawula:Le khithi yePCR enovakalelo kakhulu, elungele ukusetyenziswa iyafumaneka kwifomati ye-lyophilized (inkqubo yokumisa umkhenkce) yokugcina ixesha elide.Ikiti inokuthuthwa kwaye igcinwe kwiqondo lokushisa kwaye izinzile unyaka omnye.Ityhubhu nganye ye-premix iqulethe zonke ii-reagents ezifunekayo kwi-PCR amplification, kubandakanywa i-Reverse-transcriptase, i-Taq polymerase, i-primers, i-probes, kunye ne-dNTPs substrates. kwisixhobo sePCR ukuqhuba ulwandiso.
Ukuphendula kuqhambuko lwenoveli yekoronavirus, iLiming Bio-Products Co., Ltd. isebenze ngokukhawuleza ukuphuhlisa izixhobo ezimbini zokuxilonga ukuze iilabhoratri zezonyango nezoluntu zikwazi ukufumanisa ngokukhawuleza usulelo lwe-COVID-19.Ezi zixhobo zikulungele kakhulu ukusetyenziswa kuvavanyo olukhulu kumazwe nakwimimandla apho uqhambuko lwe-coronavirus entsha lusasazeka ngokukhawuleza, kunye nokubonelela ngoxilongo kunye nokuqinisekisa usulelo lwe-COVID-19.Ezi zixhobo zenzelwe ukusetyenziswa kuphela phantsi koGunyaziso lokuSebenzisa oluNgxamisekileyo oluchazwe kwangaphambili (PEUA).Uvavanyo lukhawulelwe kwiilabhoratri eziqinisekisiweyo phantsi kwemigaqo yabasemagunyeni kazwelonke okanye basekhaya.
Indlela yokufumanisa i-Antigen
1. Ukufumanisa i-antigen ye-Viral ihlelwa kwinqanaba elifanayo lokufumanisa ngokuthe ngqo njengokubona i-nucleic acid.Ezi ndlela zokubona ngokuthe ngqo zijonga ubungqina bentsholongwane yentsholongwane kwi-specimen kwaye ingasetyenziselwa ukuxilongwa kokuqinisekiswa.Nangona kunjalo, ukuphuhliswa kweekiti zokufumanisa i-antigen kufuna umgangatho ophezulu wee-antibodies ze-monoclonal ezinobudlelwane obuqinileyo kunye novakalelo oluphezulu olukwaziyo ukuqaphela kunye nokubamba iintsholongwane ze-pathogenic.Ngokuqhelekileyo kuthatha ngaphezu kweenyanga ezintandathu ukukhetha kunye nokwandisa i-antibody ye-monoclonal elungele ukusetyenziswa ekulungiseleleni ikiti yokubona i-antigen.
2. Okwangoku, ii-reagents zokubona ngokuthe ngqo inoveli coronavirus zisaphantsi kophando kunye nenqanaba lophuhliso.Ngoko ke, akukho kit yokufumanisa i-antigen iye yaqinisekiswa ngokweklinikhi kwaye ifumaneka ngokurhweba.Nangona kwakuxelwe ngaphambili ukuba i-diagnostic firm e-Shenzhen iye yavelisa ikiti yokufumanisa i-antigen kwaye yavavanywa ngekliniki eSpain, ukuthembeka kovavanyo kunye nokuchaneka akukwazanga ukuqinisekiswa ngenxa yobukho bemiba yekhwalithi ye-reagent.Ukuza kuthi ga ngoku, i-NMPA (yayesakuba yi-China FDA) ayizange ivume nayiphi na ikiti yokubona i-antigen yokusetyenziswa kweklinikhi okwangoku.Ukuqukumbela, iindlela ezahlukeneyo zokufumanisa ziye zaphuhliswa.Indlela nganye ineengenelo kunye nemida yayo.Iziphumo ezivela kwiindlela ezahlukeneyo zingasetyenziselwa ukuqinisekiswa kunye nokuhambelana.
3. Ukuvelisa ikhithi yovavanyo lwe-COVID-19 esemgangathweni kuxhomekeke ngamandla ekwandiseni ngexesha lophando nophuhliso.ILiming Bio-Product Co., Ltd.iikhithi zovavanyo ziyafuneka ukuba zihlangabezane nemigangatho engqongqo yokwenziwa kunye nolawulo lomgangatho ukuqinisekisa ukuba zibonelela ngemigangatho ephezulu yokusebenza kunye nokungaguquguquki.Izazinzulu zaseLiming Bio-Product Co., Ltd. zineminyaka engaphezulu kwamashumi amabini amava ekuyileni, ekuvavanyeni nasekuphuculeni izixhobo zokuxilonga ze-in vitro ukuqinisekisa elona nqanaba liphezulu lokusebenza kumanani ohlalutyo.
Ngexesha le-COVID-19 Pandemic, urhulumente waseTshayina wajongana nesidingo esikhulu sezixhobo zokuthintela ubhubhane kwiindawo ezishushu zamazwe ngamazwe.Ngomhla we-5 ka-Apreli, kwinkomfa ye-State Council Joint Prevention and Control Mechanism "Ukomeleza uLawulo loMgangatho weMpahla yezoNyango kunye nokulawula uMyalelo weMakethi", uJiang Fan, umhloli wenqanaba lokuqala kwiSebe lezoRhwebo lwangaphandle. weRhwebo, wathi, "Okulandelayo, siya kugxila kwiinzame zethu kwiinkalo ezimbini, okokuqala, ukukhawulezisa inkxaso yezoncedo zonyango ezifunekayo kuluntu lwamazwe ngamazwe, kunye nokuphucula ulawulo lomgangatho, ukulawulwa kunye nokulawulwa kweemveliso. Siza kwenza igalelo leTshayina ekuphenduleni ngokudibeneyo kubhubhane wehlabathi kunye nokwakha uluntu olunekamva ekwabelwana ngalo loluntu.
Umfanekiso 5:I-Liming Bio-Products Co., Ltd. inoveli ye-coronavirus reagent ifumene isiqinisekiso sobhaliso se-EU
Isiqinisekiso sembeko
Houshenshan
Umzobo 6. ILiming Bio-Products Co., Ltd. ixhase iWuhan Vulcan(HouShenShan) iSibhedlele saseMountain ukuba silwe nobhubhane we-COVID-19 kwaye wawongwa ngesiqinisekiso sembeko se-Wuhan Red Cross.Isibhedlele sase-Wuhan Vulcan sesona sibhedlele sidumileyo e-China esisebenza kunyango lwe-COVID-19 enzima.
Njengoko uqhambuko lwe-coronavirus entsha luqhubeka lusasazeka kwihlabathi jikelele, iNanjing Liming Bio-Products Co., Ltd. Iyanyuka ixhasa kwaye incede uluntu kwihlabathi liphela ngobuchwephesha bethu bokulwa esi soyikiso singazange sabonwa sehlabathi.Uvavanyo olukhawulezileyo losulelo lwe-COVID-19 yinxalenye ebalulekileyo yokujongana nesi soyikiso.Siyaqhubeka nokuba negalelo elibalulekileyo ngokubonelela ngamaqonga oxilongo akumgangatho ophezulu ezandleni zabasebenzi bezempilo abaphambili ukuze abantu bafumane iziphumo zovavanyo ezibalulekileyo abazidingayo.Iinzame zeLiming Bio-products Co., Ltd. kumlo ochasene nobhubhani we-COVID-19 kukuba negalelo kubuchwephesha bethu, amava, kunye nobuchule kuluntu lwamazwe ngamazwe ukuze kwakhiwe uluntu lwehlabathi lwekamva.
Cinezela ixesha elide ~ Skena kwaye Usilandele
I-imeyile: sales@limingbio.com
Iwebhusayithi: https://limingbio.com
Ixesha lokuposa: May-01-2020
