Uvavanyo olukhawulezileyo lwe-fibronectin
Ukusetyenziswa kwe-Bed
I-strongstep®Uvavanyo lwePront luvavanyo lwe-itromaolotographic lovavanyo lwe-iturenophatographic lovavanyo olujongwayo olusetyenziselwe ukubuyiselwa komgangatho we-fibronectin kwi-fibvicovaginal. Ubukho be-fibronectin kwi-Cervicovagin yeeveki eziphakathi kweeveki ezingama-22, kwiintsuku ezingama-0 kunye neeveki ezingama-3, iintsuku ezi-6 zeezinxulumene nomngcipheko okuphakathisiweyo wokuhanjiswa kwengqondo.
Itrayikhi
Ukuhanjiswa kwengqondo, kuchaziwe yiKholeji yaseMelika yeAmerican kunye ne-gynecologists njengeendawo ezingaphambi kweveki yama-37, inoxanduva lokungabikho kwe-chromosomal morbidity kunye nokusweleka kwabantu. Iimpawu zokuhanjiswa okutshintshileyo zibandakanya ukuqinisekiswa kwe-iTerrine, ukutshintsha kwe-versinal ukukhutshwa, ukopha i-vaginal, i-backche, ukungonwabisi, isisu, uxinzelelo lwe-pelvic, kunye nengcinezelo ye-pelvic, kwaye icekeceke. Isimo sokuchongwa isifo sokuchongwa kokunikezelwa kwento esongelweyo kubandakanya ukubeka iliso kwimisebenzi ye-Interine kunye nokusebenza kovavanyo lwe-jijithali yedijithali, evumela uqikelelo lwemilinganiselo yomlomo wesibeleko. Ezi ndlela zibonisiwe ukuba zinqunyelwe, njengokudinwa komgangatho omncinci (<cyentimitha ezi-3) kunye nomsebenzi we-interine wenzeka ngokwesiqhelo kwaye akanyanzelekanga ukuba afumane imfuneko yokuhanjiswa kwengqondo. Ngelixa abamakishine abaliqela be-biochemical bavavanyiwe, akukho namnye owamkelwe ngokubanzi ukuba asetyenziswe kakuhle.
I-Fetal Fibronectin (FFN), i-isforform ye-Fibronectin, yi-Gycoproterin enobunzima obunemoyarund ye-molecular enama-500,000 e-daltons. UMatsura kunye nabaSebenzi basebenzise i-monoclon antiys ebizwa ngokuba yi-FDC-6, ethi ibone ngokukodwa i-II-CS, le ndawo ichaza i-i-feat ye-dibronectin. Izifundo ze-ugogostochemicamical ze-placentae zibonakalise ukuba ffn yiyoivalelwe kwi-matrix ye-overcellium yengingqi ichaza i-junctionkwiiyunithi zomama kunye nobufundisi ngaphakathi kwesibeleko.
I-fatal fibronectin inokufunyanwa kwi-Cervicovaginal yeCervicovaginal yabasetyhini kuyo yonke indawo yokukhulelwa ngokusetyenziswa kwe-monoclosanal engekho mthethweni. I-fatal fibronectin iphakanyisiwe kwiziko le-cibvicovaginal ngexesha lokukhulelwa kwangoko kodwa incitshisiwe ukusuka kwiiveki ezingama-22 ukuya kwezingama-35 ngokukhulelwa okuqhelekileyo. Ukubaluleka kobukho bayo kwilungu lobufazi ngexesha leeveki zokukhulelwa akuqondwa. Nangona kunjalo, isenokubonisa ukukhula okuqhelekileyo kwe-trophoblast ye-trophoblast kunye neplacenta. Ukufunyanwa kwe-FFN kwi-Cervicovaginols phakathi kweeveki ezingama-22, kwiintsuku ezingama-0 kunye ne-3 yeentsuku zokumitha ezixeliweyo zichazwe ukuba zinxulunyaniswa nokunikezelwa kwe-protem kwaye phakathi kweeveki ezingama-22 ezikwiiveki ezingama-30 kwi-Asympomatic bafazi abakhulelweyo.
Umgaqo
I-strongstep®Uvavanyo lwe-FFN lusebenzisa imizobo ye-itunochromatographic, itekhnoloji yokuhambahamba. Inkqubo yovavanyo ifuna ukuba i-Sfn ye-FFN isuka kwi-Swab Swab ngokuxuba i-swab kwi-buffer isampula. Emva koko i-buffer exutywe yongezwa kwimodeli yekhasethi yovavanyo kakuhle kunye nomxube wokufuduka ecaleni kwe-membrane. Ukuba i-FFN ikhoyo kwisampulu, iya kuba yinto enobunzima nge-anticy echazayo antict edityaniswe kwibala elinemibala. Ubunzima buya kuthi emva koko buboshwe nge-antidy yesibini ye-fffer kwi-nitrocellulose membrane. Ukubonakala komgca wovavanyo obonakalayo kunye nomgca wokulawula uya kubonisa isiphumo esifanelekileyo.
Izinto zekhithi
| 20 Nganye nganyeackIzixhobo zovavanyo lwe-ED | Isixhobo ngasinye siqukethe umtya onemibala enombala kunye nokwenza izinto ezisebenzayo ezihlanganisiweyo kwimimandla ehambelanayo. |
| 2UkukhutshwaI-Buffer Vial | I-0.1 M phosphate ye-phosphate ye-saline (PBs) kunye ne-0.02% ye-sodium aze. |
| I-1 yoLawulo lweSwab (ngesicelo kuphela) | Iqulethe i-FFN kunye ne-sodium aze. Ulawulo lwangaphandle. |
| I-1 ye-swab (ngesicelo kuphela) | Ayiqulatha iFFN. Ulawulo lwangaphandle. |
| 20 Ukukhupha iityhubhu | Ukusetyenziswa kwengqondo yokusetyenziswa. |
| 1 Indawo yokusebenza | Indawo yokubamba i-vials ye-buffer kunye neetyhubhu. |
| 1 Iphakheji | Uqeqesho lokusebenza. |
Izinto ezifunekayo kodwa azibonelelwanga
| Ixesha | Ukusetyenziswa kwexesha. |
UKULUMKELA
■ Ingcali kwi-vitro yokusetyenziswa kuphela.
■ Musa ukusebenzisa emva komhla wokuphelelwa oboniswe kwiphakheji. Sukusebenzisa uvavanyo ukuba ibhedi yayo yonakalisiwe. Sukuyifumana kwakhona iimvavanyo.
■ Le khiti inemveliso yemvelaphi yezilwanyana. Ulwazi oluqinisekisiweyo lwemvelaphi kunye / okanye ilizwe lezilwanyana aliqinisekisi ngokupheleleyo ukungabikho kweearhente ze-pithogenic ezinikiweyo. Ke ngoko, kucetyiswa ukuba ezi mveliso zinyangwa njengokungasuleleki, kwaye zisingathethwa zizinto zokhuseleko eziqhelekileyo (musa ukufaka okanye i-inhale).
■ Khusela ungcoliseko olunqamlezileyo lwemodeli ngokusebenzisa isikhongozelo esitsha sengqokelela kwinqaku ngalinye elifunyenweyo.
■ funda yonke inkqubo ngononophelo ngaphambi kokwenza naluphi na uvavanyo.
■ Ungayityi, usele okanye umsi kwindawo apho iisampulu kunye neekhitshi ziphathwa. Phatha zonke iimodeli ngokungathi ziqulathe iiarhente zosulelo. Observe established precautions against microbiological hazards throughout the procedure and follow the standard procedures for proper disposal of specimens. Nxiba impahla yokhuselo enjengeengubo zelebhu, iiglavu ezihlangeneyo kunye nokukhuseleka kwamehlo xa kuthathwa iisampulu.
■ Musa ukungahambelani okanye udibanise iirejista ukusuka kwiindawo ezahlukeneyo. Sukudibanisa isisombululo sebhotile yebhotile.
■ Ukuqina kunye nobushushu kunokubachaphazela kakubi iziphumo.
■ Xa i-Assay Sgramme igqityiwe, ilahla i-swabs ngononophelo emva kokuziphindezela nge-121 ° C ubuncinci imizuzu engama-20. Ngenye indlela, banokuthi baphathwe nge-0.5% ye-sodium hypochloride (okanye indlu-i-veach) iyure enye ngaphambi kokulahlwa. Izixhobo zokuvavanya ezisetyenzisiweyo kufuneka zilahliwe ngokungqinelana nendawo yengingqi, yelizwe kunye / okanye imigaqo ye-Federal.
■ Musa ukusebenzisa ibhulegy ye-cytology kunye nezigulana ezikhulelweyo.
Ukugcinwa kunye nokuzinza
■ Ikhithi kufuneka igcinwe kwi-2-30 ° C kude kube ngumhla wokuphelelwa kwingxowa etywiniweyo.
■ Uvavanyo kufuneka luhlale kwi-pouch etywiniweyo de isebenzise.
■ Musa ukundikhupha.
■ Ixhala kufuneka lithathwe ukukhusela izinto kule khithi kungcoliseko. Sukusebenzisa ukuba kukho ubungqina bongcoliseko lwe-rotial okanye i-puciption. Ungcoliseko lwebhayoloji lokusasaza izixhobo, izikhongozeli okanye iirejints zingakhokelela kwiziphumo zobuxoki.
Ukuqokelelwa kwe-Pecimen kunye nokuGcina
■ sebenzisa i-dacron kuphela okanye iRayon enamafutha e-steles ene-shafts yeplastiki. Kucetyiswa ukusebenzisa i-swab ebonelelwe yi-Kits Peecter (i-swabs ayikho kule khithi, kulwazi loku-odola, nceda tsalela uMvelisi okanye inombolo yengingqi, inombolo ye-Cataloge yi-207000). I-Swabs evela kwabanye abathengisi akazange aqinisekiswe. I-swabs ngeingcebiso zomqhaphu okanye ii-shaftts zenkuni azicetyiswa.
■ I-Cerervicovaval ifunyenwe kwi-posterix ye-posterix yelungu lobufazi. Inkqubo yokuqokelela yenzelwe ukuba ibe nobulali. Ingqokelela okanye iqhinga elinamandla, ixhaphakile kwinkcubeko ye-microbiological, ayimfuneko. Ngexesha loviwo oluphambili, ngaphambi kokuba kuphinde uviwo okanye ubuqhetseba bephecana okanye ukujikeleza i-faginal i-Pipt Khupha i-Posterix ye-Posterina ye-Postericovaval. Iinzame ezilandelayo zokugcwalisa i-App i-Appliched inokungasebenzi uvavanyo. Susa uMfaki-sicelo wenze uvavanyo njengoko kubhekiswa ngezantsi.
■ Beka i-swab kwityhubhu yokukhupha, ukuba uvavanyo lungaqhutywa ngokukhawuleza. Ukuba uvavanyo kwangoko alunakwenzeka, iisampulu zesigulana kufuneka zibekwe kwityhubhu yothutho eyomileyo yokugcina okanye ukuthutha. I-Swabs inokugcinwa iiyure ezingama-24 kubushushu begumbi (15-30 ° C) okanye kwiveki e-4 nge-4 ° C okanye engaphezulu kwe-4 ° C okanye engaphezulu kwe-6 ° C. Zonke iimodeli kufuneka zivunyelwe ukufikelela kubushushu begumbi le-1-30 ° C ngaphambi kovavanyo.
Inkqubo
Yiza novavanyo, iisampuli, i-buffer kunye / okanye ulawulo kubushushu begumbi (15-30 ° C) ngaphambi kokusebenzisa.
■ Beka ityhubhu yokukhupha ecocekileyo kwindawo echongiweyo yomsebenzi. Yongeza i-1ml ye-buffer yokukhupha kwityhubhu yokukhupha.
■ Beka i-swimpaimen wible kwityhubhu. Ngamandla uxuba isisombululo ngokujikeleza i-swab ngamandla e-Tube kalishumi kalishumi (ngelixa unamanzi). Iziphumo ezilungileyo zifunyanwa xa i-curimen idityaniswa ngamandla kwisisombululo.
■ kutyibilika kulwelo oluninzi kangangoko kunokwenzeka kwi-swab ngokucinezela icala le-cube eguqukayo njengoko i-Swab isuswe. Ubuncinci i-1/2 yesisombululo se-buffer yesampulu kufuneka ihlale kwityhubhu yokufuduka eyaneleyo. Beka i-cap kwityhubhu ekhutshiweyo.
Lahla i-swab kwi-bioharser yenkunkuma efanelekileyo yenkunkuma.
■ I-capimes ekhutshiweyo inokugcina kubushushu begumbi kangangemizuzu engama-60 ngaphandle kokuchaphazela iziphumo zovavanyo.
■ Susa uvavanyo kwingxoxo yayo etywiniweyo, kwaye uyibeka kwindawo ecocekileyo nenomgangatho. Faka ilebhile ifowuni kunye nokuchongwa kwesigulana okanye ukulawula. Ukufumana isiphumo esifanelekileyo, i-assay kufuneka yenziwe ngaphakathi kwiyure enye.
■ Yongeza amaconsi ama-3 (malunga ne-100 μl) yesampulu ekhutshelweyo kwityhubhu yokukhupha kwisampulu yekhasethi yovavanyo.
Kulumkele ukubopha iibhubhu ze-tubs ze-air kwi-specian kakuhle (s), kwaye ungalahle nasiphi na isisombululo kwifestile yokujonga.
Njengoko uvavanyo luqala ukusebenza, uya kubona umbala uqhula ngaphaya kwe-membrane.
■ Lindela iqela lemibala (s) lokuvela. Isiphumo kufuneka sifundwe kwimizuzu emi-5. Musa ukutolika iziphumo emva kwemizuzu emi-5.
Lahla iityhubhu zovavanyo ezisetyenzisiweyo kunye neekhasethi zekhasethi zovavanyo kwi-bitser yenkunkuma efanelekileyo.
Ukuguquli kweziphumo
| IkhanyanisiIsiphumo:
| Iibhendi ezimbini ezinemibala zivela kwi-membrane. Ibhendi enye ivela kwingingqi yolawulo (c) kwaye enye ibhendi ivela kummandla wovavanyo (t). |
| EngalungangaIsiphumo:
| Iqela elinye kuphela elinemibala livela kwingingqi yolawulo (c). Akukho bandi zibonakalayo zibonakalayo kwingingqi yovavanyo (t). |
| AyisebenziIsiphumo:
| Ibhendi yolawulo iyasilela ukuvela. Iziphumo ezivela kulo naluphi na uvavanyo olungavelisi ibhendi yolawulo ngexesha lokufunda elichaziweyo kufuneka lilahlwe. Nceda ujonge inkqubo kwaye uphinde uphinde ngovavanyo olutsha. Ukuba ingxaki iyaqhubeka, ukuyeka ukusebenzisa i-kit kwangoko kwaye uqhagamshelane nomsasazi wakho wengingqi. |
PHAWULA:
1. Ubunzulu bombala kwingingqi yovavanyo (t) bungahluka ngokuxhomekeka kuxinzelelo lwezinto ezikhoyo ezikhoyo kwinqaku. Kodwa inqanaba lezinto ezinokubakho azinakugqitywa kolu vavanyo.
2. Ivolumu engonelanga, inkqubo yokusebenza engachanekanga, okanye yenza uvavanyo oluphelelwe lixesha zezona zizathu zibalulekileyo zokungaphumeleli kwebhendi.
ULAWULO LWEMEKO
■ Ulawulo lwenkqubo lwangaphakathi lubandakanyiwe kuvavanyo. Ibhendi enemibala evelayo kwingingqi yolawulo (c) ithathwa njengolawulo lwenkqubo yangaphakathi. Iqinisekisa ivolumu eyoneleyo kunye nenkqubo yenkqubo efanelekileyo.
■ Ulawulo lwenkqubo lwangaphandle lunokubonelelwa (ngesicelo kuphela) kwiikhithi ukuqinisekisa ukuba iimvavanyo zisebenza ngokufanelekileyo. Kananjalo, ulawulo lunokusetyenziselwa ukubonisa ukusebenza ngokufanelekileyo ngumsebenzi wovavanyo. Ukwenza uvavanyo olululo okanye olubi, gcwalisa amanyathelo kwiCandelo loVavanyo lweCandelo lokunyanga i-swab ngendlela efanayo njenge-swab.
UKUHLAZIYWA KOKUVAVANYA
1. Esi sidumbu sinokusetyenziselwa ukubongolwa okukuko kwi-fibronectin ye-fibronevaginal.
2. Iziphumo zovavanyo kufuneka zisetyenziswe ngokudibeneyo kunye nenye idatha yeklinikhi kunye nelebhu yolawuloguli.
3. Iisampulu kufuneka zifunyanwe ngaphambi koviwo lwedijithali okanye ukuqhekeka kwe-cervix. Ukugcoba komlomo wesibeleko kunokukhokelela kwiziphumo ezilungileyo zobuxoki.
4. Iisampuli akufuneki ziqokelelwe ukuba isigulana sibe neentlobano zesini ngaphakathi kweeyure ezingama-24 ukuphelisa iziphumo ezilungileyo.
I-5. Izigulana ezinomsindo otyisiweyo okanye owaziwayo, i-Placenta Previa, okanye ukonakala okanye ukonakala komzimba okanye ukonakala komntu ongafanelekanga akufuneki kuvavanywe.
I-6. Izigulana ezine-criflage akufuneki zivavanywe.
I-7. Iimpawu zentsebenzo ze-certstep®Uvavanyo lwe-FFN lusekwe kwizifundo kwabasetyhini abanezivalo ze-nyerton. Intsebenzo ayiqinisekiswanga kwizigulana ezinemivambi emininzi, umz, amawele.
I-8. I-stistep®Uvavanyo lwe-FFN alwenzelwe ukuba lwenziwe phambi kobukho be-rambranes kunye nokugqobhoza kwe-Mniotic Membrane kufuneka kukhutshwe ngaphambi kokuqhuba uvavanyo.
Iimpawu zentsebenzo
Itheyibhuli: I-Wortstep® VFN Uvavanyo vs. Omnye uvavanyo lwe-FFN
| Imvakalelo yesihlobo: I-97.96% (89.13% -99.95%) * Ubungqina bokuba: I-98.73% (95.50% -99.85%) * Isivumelwano ngokubanzi: I-98.55% (95.82% -99.70%) * * I-95% intelekelelo yokuphumla |
| Olunye uphawu |
| ||
| + | - | Iyonke | |||
| Amandla®fFn Vavanyo | + | 48 | 2 | 50 | |
| - | 1 | 156 | 157 | ||
|
| 49 | 158 | 207 | ||
Imvakalelo yohlalutyo
Isixa esisezantsi esibonakalayo se-FFN kwimo ekhutshiweyo yi-50μg / l.
Phakathi kwabasetyhini, amanqanaba aphezulu (≥ I-0.050 μg / ML) (1 x 10-7 Mmol / L) Iiveki ezi-6, iintsuku ezi-6 zibonisa ukwenziwa kweentsuku ezili-14 ukusuka ukuqokelelwa kwesampulu. Phakathi kwamabhinqa ama-Asymptomatic, amanqanaba aphezulu e-FFN phakathi kweeveki ezingama-22, kwiintsuku ezingama-0 kunye neeveki ezingama-30, iintsuku ezi-6 zibonisa umngcipheko wokukhula kwiiveki ezingama-34, iintsuku ezi-6 zokumitha. I-cutoff ye-50 μG / L FFN yasekwe kwisifundo seMildithin senziwe ukuvavanya umbutho phakathi kwentetho ye-fibronectin ngexesha lokukhulelwa kunye nokukhulelwa kokukhulelwa.
Izinto eziphazamisayo
Inkathalo kufuneka ithathwe ukuba ingangcolisekisi okanye i-cervicovaginal okanye i-cirvicovaginal enee-lungisa, ii-soaps, iintsholongwane, okanye iikhrim. I-Lubristants okanye i-crims inokuthi iphazamise emzimbeni I-SOAPS okanye iintsholongwane zinokuphazamisana no-Antigder-Antign Reaction.
Izinto eziphazamisayo ezinokubakho zavavanywa ekugxinisweni ezinokufumaneka ngokuvakalayo kwi-Cervicovaginal. Ezi zinto zilandelayo aziphazamisi kwi-Assay xa ivavanywa kumanqanaba abolekileyo.
| Into | Uxinzelelo | Into | Uxinzelelo |
| Amppillin | 1.47 MG / ML | I-Prostaglandin F2 | aI-0.033 mg / ml |
| Erythromycin | I-0.272 mg / ml | I-Prostaglandin E2 | I-0.033 mg / ml |
| Umchamo wasemamani 3rd Trimester | I-5% (i-vol) | I-MonOnstistatr (Mic Ponaole) | I-0.5 mg / ml |
| I-Oxetocin | 10 IU / ML | I-Indigo Carmine | I-0.232 mg / ml |
| I-Terbutaline | I-3.59 mg / ml | Inyani | I-0.849 mg / ml |
| DexomethaShasone | 2.50 mg / ml | I-Betadiner Gel | I-10 mg / ml |
| Mgso4•7h2o | 1.49 mg / ml | I-Betadiner Ciness | I-10 mg / ml |
| IRitodrine | I-0.33 mg / ml | K-yr jelly | I-62.5 mg / ml |
| I-Dermicolr 2000 | I-25.73 mg / ml |
Izalathiso zoncwadi
I-1. Ikholeji yaseMelika yama-Obstetrikians kunye ne-gynecologists. Umsebenzi wokusebenza. I-Bulletin yezobugcisa, inombolo ye-133, ngo-Okthobha, 1989.
I-2. I-Creasy RK, i-RECINICK R. I-REALNATICH YEMISEBENZI YAMABHONO: Imigaqo kunye nokuziqhelanisa. IPhiladelphia: I-WB Saunders; Ngo-1989.
I-3. I-Creasy RK, i-merkattz ir. Ukuthintela ukuzala kokuqala: Uluvo lweklinikhi. I-Gynet Gyneol 1990; 76 (i-Shortl 1): 2s-4s.
I-4. I-Morrison JC. I-PREETM YOKUGQIBELA: Iphazili ifanelekile. I-Obynet Gyneol 1990; 76 (i-Shortl 1): 5s-12s-12s.
5. Lockwood cj, senyei ae, dische m, casal dc, et al. I-Fetal Fibronectin kwi-Cervical kunye ne-Veginal, njengeziqithi zokuqala zokuhanjiswa. I-Enge Engen J MED 1991; 325: 669-74.
Iglosari yesimboli
|
| Inombolo yekhathalogu |  | Ukunqongophala kobushushu |
 | Nxibelelana nemiyalelo yokusetyenziswa |
| Ikhowudi yeBatch |
 | Kwisixhobo sonyango lweVitrolostic |  | Sebenzisa |
 | Umvelisi |  | Iqulethwe ngokwaneleyo |
 | SUKUFUMANA |  | Ummeli ogunyazisiweyo kuluntu lwaseYurophu |
 | Imakishwe ngokwesixhobo sezonyango i-IVD 98/79 / EC | ||
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Isixhobo soVavanyo lwe-Fibbronectin fit
Ukuhanjiswa kwengqondo, kuchaziwe yiKholeji yaseMelika yeAmerican kunye ne-gynecologists njengeendawo ezingaphambi kweveki yama-37, inoxanduva lokungabikho kwe-chromosomal morbidity kunye nokusweleka kwabantu. Iimpawu zokuhanjiswa okutshintshileyo zibandakanya ukuqinisekiswa kwe-iTerrine, ukutshintsha kwe-versinal ukukhutshwa, ukopha i-vaginal, i-backche, ukungonwabisi, isisu, uxinzelelo lwe-pelvic, kunye nengcinezelo ye-pelvic, kwaye icekeceke. Isimo sokuchongwa isifo sokuchongwa kokunikezelwa kwento esongelweyo kubandakanya ukubeka iliso kwimisebenzi ye-Interine kunye nokusebenza kovavanyo lwe-jijithali yedijithali, evumela uqikelelo lwemilinganiselo yomlomo wesibeleko.
Uvavanyo lwe-facestep ® i-fatal fibronectin luvavanyo lwe-itromaolotographic loncwadi lwe-itromaolotographic ilungiselelwe ukuba lusetyenziselwe ukufumanisa ukufunyanwa komgangatho we-fibronevatin kwi-Cervicovaginal kwezi mpawu zilandelayo:
Isebenziseka kakuhle:Inkqubo yenqanaba elinye kuvavanyo olufanelekileyo
Khawuleza:Yimizuzu eli-10 kuphela efunekayo ngexesha lesigulana esifanayo
Izixhobo-Simahla:Izibhedlele ezinomthombo okanye ukusetwa kweklinikhi kunokwenza olu vavanyo
Ihanjiswa:Ubushushu begumbi (2 ℃ -30 ℃)
